The hotly-anticipated one and only vice presidential debate between Senator Kamala Harris of California and Vice President Mike Pence will take place on Wednesday night in Salt Lake City, Utah. During the debate, Joe Biden's running mate is expected to direct her energy at a person who will not be physically present at the debate stage in Salt Lake City, Utah.

There are no prizes for guess that the person is President Donald Trump. Although Harris will be going up against Pence on the debate stage, the Senator's vice presidential nominee’s communications director Liz Allen told reporters before the show kick-off at 9 p.m. ET that the debate will revolve around the president's failed leadership and Trump-Pence record of failing Americans since 2016.

Aside from that, Allen said the debate will be about the American families that are trying to survive the still raging coronavirus pandemic. This is the first debate since Trump revealed that he had contracted coronavirus, and comes as he is sidelined from the campaign, self-isolating in the White House after spending three days at Walter Reed National Military Medical Center as he recovers from COVID-19.

The pandemic has been the leading issue in the US presidential race 2020 since the outbreak swept the country earlier this year, with more 210,000 succumbing to the virus and over 7.5 million confirmed cases across America. And with Trump contracting the disease, the issue is likely to dominate the debate.

The Democratic presidential nominee has been criticizing Trump for the past seven months for downplaying the severity of the outbreak initially. Aside from that, Biden accuses the president of making a messing of the federal government’s response.

According to Allen, Pence, who spearheads the White House coronavirus task force has to defend this record tonight at the debate. Moreover, she said Harris will not leave a stone unturned in a bid to make a case of the Trump administration's failed leadership, and blaming it for failing the American people, Fox News reported.

Following in the footsteps of Biden, the former vice president's senior adviser Symone Sanders predicted that Harris will address voters at home, rather than questioning Pence. The same strategy Biden adopted during the first presidential debate.

Pence, on the other hand, will try to defend the administration’s criticized record restricting the spread of the coronavirus. The vice president will be talking about the action this administration has taken during the early stage of the pandemic with great details, according to Pence chief of staff March Short.